Oral Cavity Squamous Cell Carcinoma

general

A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and

Centers

284

Active Trials

$3.3B

Cancer Funding

Specific Cancer Types(7)

Name	Centers	Active Trials
Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7	66	72
Recurrent Oral Cavity Squamous Cell Carcinoma	48	75
Tongue Squamous Cell Carcinoma	40	42
Refractory Oral Cavity Squamous Cell Carcinoma	20	20
Stage IVB Verrucous Carcinoma of the Oral Cavity	8	—
Unresectable Oral Cavity Squamous Cell Carcinoma	5	5
Stage III Oral Cavity Squamous Cell Carcinoma	4	—

Top Centers for Oral Cavity Squamous Cell Carcinoma(78)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Winship Cancer InstituteAtlanta, GA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	10	$4M	84.0
2	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive High-Volume Research Center	High-Volume Research Center	7	$3M	83.5
3	Cleveland Clinic Cancer CenterCleveland, OH High-Volume Research Center	High-Volume Research Center	5	$621K	79.8
4	Holden Comprehensive Cancer CenterIowa City, IA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	4	$193K	77.1
5	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	5	—	62.8
6	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive Active Research Program	Active Research Program	5	—	62.8
7	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive Active Research Program	Active Research Program	10	—	62.8
8	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive Active Research Program	Active Research Program	4	—	62.8
9	Medical College of Wisconsin Cancer CenterMilwaukee, WI Active Research Program	Active Research Program	5	—	62.8
10	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive Active Research Program	Active Research Program	7	—	62.8
11	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive Active Research Program	Active Research Program	7	—	62.8
12	Dartmouth Cancer CenterLebanon, NH NCI Comprehensive Active Research Program	Active Research Program	7	—	62.8
13	University of Illinois Cancer CenterChicago, IL Active Research Program	Active Research Program	10	—	62.8
14	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR Active Research Program	Active Research Program	7	—	62.8
15	Boston University Cancer CenterBoston, MA Active Research Program	Active Research Program	7	—	62.8
16	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive Active Research Program	Active Research Program	5	—	62.8
17	Cancer Center at IllinoisUrbana, IL Active Research Program	Active Research Program	8	—	62.8
18	Penn State Cancer InstituteHershey, PA Active Research Program	Active Research Program	5	—	62.8
19	The University of Vermont Cancer CenterBurlington, VT Active Research Program	Active Research Program	6	—	62.8
20	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	4	$381K	61.9
21	Laura and Isaac Perlmutter Cancer Center at NYU Langone HealthNew York, NY NCI Comprehensive Active Research Program	Active Research Program	3	$339K	61.3
22	Montefiore Einstein Comprehensive Cancer CenterBronx, NY NCI Comprehensive Active Research Program	Active Research Program	6	$336K	60.8
23	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive Active Research Program	Active Research Program	4	$308K	60.3
24	Dan L Duncan Comprehensive Cancer Center at Baylor College of MedicineHouston, TX NCI Comprehensive Active Research Program	Active Research Program	2	$167K	59.2
25	Sandra and Edward Meyer Cancer Center at Weill Cornell MedicineNew York, NY Active Research Program	Active Research Program	—	$1M	49.5
26	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive Active Research Program	Active Research Program	2	$1M	49.0
27	University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer CenterBaltimore, MD NCI Comprehensive Active Research Program	Active Research Program	—	$1M	48.5
28	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	1	$827K	48.0
29	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive Active Research Program	Active Research Program	4	$773K	47.4
30	Loma Linda University Cancer CenterLoma Linda, CA Active Research Program	Active Research Program	—	$679K	46.9
31	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	7	—	45.4
32	UNC Lineberger Comprehensive Cancer CenterChapel Hill, NC NCI Comprehensive Active Research Program	Active Research Program	6	—	45.4
33	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
34	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
35	Vanderbilt-Ingram Cancer CenterNashville, TN NCI Comprehensive Active Research Program	Active Research Program	6	—	45.4
36	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
37	Duke Cancer InstituteDurham, NC NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
38	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
39	USC Norris Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive Active Research Program	Active Research Program	5	—	45.4
40	University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
41	Moffitt Cancer CenterTampa, FL NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
42	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
43	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
44	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive Active Research Program	Active Research Program	6	—	45.4
45	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical Active Research Program	Active Research Program	6	—	45.4
46	UCI Chao Family Comprehensive Cancer CenterOrange, CA NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
47	Atrium Health Wake Forest Baptist Comprehensive Cancer CenterWinston-Salem, NC NCI Comprehensive Active Research Program	Active Research Program	2	—	45.4
48	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical Active Research Program	Active Research Program	4	—	45.4
49	Rutgers Cancer InstituteNew Brunswick, NJ NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
50	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive Active Research Program	Active Research Program	3	—	45.4
51	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	4	—	45.4
52	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX Active Research Program	Active Research Program	3	—	45.4
53	University of Cincinnati Cancer CenterCincinnati, OH Active Research Program	Active Research Program	2	—	45.4
54	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL Active Research Program	Active Research Program	3	—	45.4
55	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ Active Research Program	Active Research Program	3	—	45.4
56	Northwell Health Cancer InstituteNew York, NY Active Research Program	Active Research Program	3	—	45.4
57	Tampa General Hospital Cancer InstituteTampa, FL Active Research Program	Active Research Program	2	—	45.4
58	University of Wisconsin Carbone Cancer CenterMadison, WI NCI Comprehensive		5	—	29.4
59	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive		1	—	29.4
60	Cedars-Sinai CancerLos Angeles, CA		1	—	29.4
61	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical		1	—	29.4
62	Stony Brook Cancer CenterStony Brook, NY		1	—	29.4
63	Georgia Cancer Center, Augusta UniversityAugusta, GA		1	—	29.4
64	Upstate Cancer CenterSyracuse, NY		3	—	29.4
65	Princess Margaret Cancer CentreToronto, ON		—	—	29.4
66	Louisiana Cancer Research CenterNew Orleans, LA		1	—	29.4
67	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive		—	$754M	—
68	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive		1	$738M	—
69	Simmons Comprehensive Cancer Center UT Southwestern Medical CenterDallas, TX NCI Comprehensive		1	$438M	—
70	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive		2	$368M	—
71	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive		2	$276M	—
72	UF Health Cancer InstituteGainesville, FL NCI Clinical		1	$257M	—
73	Wilmot Cancer Institute, UR MedicineRochester, NY NCI Clinical		2	$153M	—
74	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive		3	$136M	—
75	UofL James Graham Brown Cancer CenterLouisville, KY		2	$59M	—
76	Ellis Fischel Cancer Center, MU Health CareColumbia, MO		1	$47M	—
77	University of Texas Medical Branch Cancer CenterGalveston, TX		2	$15M	—
78	BC CancerVancouver, BC		—	—	—

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →