Loss of Heterozygosity

specific

A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.

Centers

Active Trials

$14M

Cancer Funding

Top Centers for Loss of Heterozygosity(47)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$6M	68.2
2	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive Active Research Program	Active Research Program	—	$2M	67.4
3	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive Active Research Program	Active Research Program	—	$2M	66.7
4	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive Active Research Program	Active Research Program	—	$2M	66.0
5	Sandra and Edward Meyer Cancer Center at Weill Cornell MedicineNew York, NY Active Research Program	Active Research Program	—	$1M	65.2
6	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive Active Research Program	Active Research Program	—	$650K	64.5
7	Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	—	$576K	63.7
8	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	—	$208K	63.0
9	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	—	$159K	62.2
10	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive		—	—	47.7
11	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive		—	—	47.7
12	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive		—	—	47.7
13	Dan L Duncan Comprehensive Cancer Center at Baylor College of MedicineHouston, TX NCI Comprehensive		—	—	47.7
14	Duke Cancer InstituteDurham, NC NCI Comprehensive		—	—	47.7
15	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive		—	—	47.7
16	Winship Cancer InstituteAtlanta, GA NCI Comprehensive		—	—	47.7
17	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive		—	—	47.7
18	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive		—	—	47.7
19	University of Colorado Cancer CenterAurora, CO NCI Comprehensive		—	—	47.7
20	Moffitt Cancer CenterTampa, FL NCI Comprehensive		—	—	47.7
21	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive		—	—	47.7
22	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive		—	—	47.7
23	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive		—	—	47.7
24	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical		—	—	47.7
25	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive		—	—	47.7
26	Medical College of Wisconsin Cancer CenterMilwaukee, WI		—	—	47.7
27	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive		—	—	47.7
28	UMass Memorial Health Cancer CenterWorcester, MA		—	—	47.7
29	Cleveland Clinic Cancer CenterCleveland, OH		—	—	47.7
30	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical		—	—	47.7
31	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive		—	—	47.7
32	University of Illinois Cancer CenterChicago, IL		—	—	47.7
33	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical		—	—	47.7
34	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive		—	—	47.7
35	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR		—	—	47.7
36	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive		—	—	47.7
37	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive		—	—	47.7
38	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX		—	—	47.7
39	Cancer Center at IllinoisUrbana, IL		—	—	47.7
40	Penn State Cancer InstituteHershey, PA		—	—	47.7
41	University of Cincinnati Cancer CenterCincinnati, OH		—	—	47.7
42	Georgia Cancer Center, Augusta UniversityAugusta, GA		—	—	47.7
43	The University of Vermont Cancer CenterBurlington, VT		—	—	47.7
44	University of Texas Medical Branch Cancer CenterGalveston, TX		—	—	47.7
45	Loma Linda University Cancer CenterLoma Linda, CA		—	—	47.7
46	Tampa General Hospital Cancer InstituteTampa, FL		—	—	47.7
47	Louisiana Cancer Research CenterNew Orleans, LA		—	—	47.7

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →