Intrahepatic Cholangiocarcinoma

general

A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor.

Centers

161

Active Trials

$2.4B

Cancer Funding

Specific Cancer Types(3)

Name	Centers	Active Trials
Unresectable Intrahepatic Cholangiocarcinoma	60	53
Resectable Intrahepatic Cholangiocarcinoma	20	20
Metastatic Intrahepatic Cholangiocarcinoma	18	18

Top Centers for Intrahepatic Cholangiocarcinoma(76)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Stony Brook Cancer CenterStony Brook, NY High-Volume Research Center	High-Volume Research Center	2	$439K	81.8
2	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	7	—	69.3
3	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	1	$3M	68.9
4	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive Active Research Program	Active Research Program	1	$2M	68.4
5	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive Active Research Program	Active Research Program	7	—	68.4
6	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive Active Research Program	Active Research Program	5	—	68.4
7	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	2	$2M	67.9
8	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive Active Research Program	Active Research Program	3	$1M	66.4
9	USC Norris Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive Active Research Program	Active Research Program	3	—	66.1
10	Moffitt Cancer CenterTampa, FL NCI Comprehensive Active Research Program	Active Research Program	2	—	66.1
11	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive Active Research Program	Active Research Program	4	—	66.1
12	University of Cincinnati Cancer CenterCincinnati, OH Active Research Program	Active Research Program	4	—	66.1
13	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive Active Research Program	Active Research Program	2	$1M	65.9
14	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive Active Research Program	Active Research Program	3	$678K	64.9
15	Duke Cancer InstituteDurham, NC NCI Comprehensive Active Research Program	Active Research Program	1	$565K	64.4
16	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	1	$397K	63.4
17	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
18	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
19	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
20	Vanderbilt-Ingram Cancer CenterNashville, TN NCI Comprehensive Active Research Program	Active Research Program	4	—	48.2
21	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive Active Research Program	Active Research Program	4	—	48.2
22	Simmons Comprehensive Cancer Center UT Southwestern Medical CenterDallas, TX NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
23	Laura and Isaac Perlmutter Cancer Center at NYU Langone HealthNew York, NY NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
24	Winship Cancer InstituteAtlanta, GA NCI Comprehensive Active Research Program	Active Research Program	3	—	48.2
25	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive Active Research Program	Active Research Program	4	—	48.2
26	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
27	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive Active Research Program	Active Research Program	3	—	48.2
28	University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program	Active Research Program	4	—	48.2
29	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
30	UF Health Cancer InstituteGainesville, FL NCI Clinical Active Research Program	Active Research Program	3	—	48.2
31	Montefiore Einstein Comprehensive Cancer CenterBronx, NY NCI Comprehensive Active Research Program	Active Research Program	1	—	48.2
32	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
33	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	4	—	48.2
34	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
35	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical Active Research Program	Active Research Program	4	—	48.2
36	Medical College of Wisconsin Cancer CenterMilwaukee, WI Active Research Program	Active Research Program	2	—	48.2
37	Cedars-Sinai CancerLos Angeles, CA Active Research Program	Active Research Program	2	—	48.2
38	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive Active Research Program	Active Research Program	3	—	48.2
39	Cleveland Clinic Cancer CenterCleveland, OH Active Research Program	Active Research Program	2	—	48.2
40	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical Active Research Program	Active Research Program	3	—	48.2
41	Dartmouth Cancer CenterLebanon, NH NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
42	University of Illinois Cancer CenterChicago, IL Active Research Program	Active Research Program	5	—	48.2
43	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical Active Research Program	Active Research Program	3	—	48.2
44	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive Active Research Program	Active Research Program	2	—	48.2
45	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR Active Research Program	Active Research Program	3	—	48.2
46	Boston University Cancer CenterBoston, MA Active Research Program	Active Research Program	2	—	48.2
47	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX Active Research Program	Active Research Program	1	—	48.2
48	Cancer Center at IllinoisUrbana, IL Active Research Program	Active Research Program	5	—	48.2
49	Penn State Cancer InstituteHershey, PA Active Research Program	Active Research Program	1	—	48.2
50	The Jackson Laboratory Cancer CenterBar Harbor, ME NCI Basic_laboratory Active Research Program	Active Research Program	1	—	48.2
51	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ Active Research Program	Active Research Program	3	—	48.2
52	The University of Vermont Cancer CenterBurlington, VT Active Research Program	Active Research Program	1	—	48.2
53	Northwell Health Cancer InstituteNew York, NY Active Research Program	Active Research Program	1	—	48.2
54	University of Texas Medical Branch Cancer CenterGalveston, TX Active Research Program	Active Research Program	2	—	48.2
55	Loma Linda University Cancer CenterLoma Linda, CA Active Research Program	Active Research Program	1	—	48.2
56	Murtha Cancer Center at Walter Reed BethesdaBethesda, MD Active Research Program	Active Research Program	1	—	48.2
57	Tampa General Hospital Cancer InstituteTampa, FL Active Research Program	Active Research Program	1	—	48.2
58	Louisiana Cancer Research CenterNew Orleans, LA Active Research Program	Active Research Program	2	—	48.2
59	Mount Sinai Tisch Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$1M	47.5
60	OHSU Knight Cancer InstitutePortland, OR NCI Comprehensive Active Research Program	Active Research Program	1	$1M	47.0
61	Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CA NCI Basic_laboratory Active Research Program	Active Research Program	—	$696K	45.5
62	UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, CA NCI Comprehensive Active Research Program	Active Research Program	—	$363K	43.0
63	Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	1	$99K	42.5
64	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive		—	—	28.3
65	University of Wisconsin Carbone Cancer CenterMadison, WI NCI Comprehensive		3	—	28.3
66	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive		—	—	28.3
67	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive		1	—	28.3
68	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL		3	—	28.3
69	Princess Margaret Cancer CentreToronto, ON		—	—	28.3
70	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive		—	$655M	—
71	UNC Lineberger Comprehensive Cancer CenterChapel Hill, NC NCI Comprehensive		1	$569M	—
72	Dan L Duncan Comprehensive Cancer Center at Baylor College of MedicineHouston, TX NCI Comprehensive		—	$484M	—
73	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive		—	$262M	—
74	UCI Chao Family Comprehensive Cancer CenterOrange, CA NCI Comprehensive		1	$185M	—
75	UMass Memorial Health Cancer CenterWorcester, MA		1	$155M	—
76	Rutgers Cancer InstituteNew Brunswick, NJ NCI Comprehensive		—	$123M	—

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →