BRCA2 Gene Mutation

general

A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small deletions or insertions (1-20 bases) account for the majority of mutations in the BRCA2 gene. Most of these alterations result in a truncated form of the breast cancer type 2 susceptibility protein. Mutations in the BRCA2 gene predispose males to breast cancer.

Centers

Active Trials

$1.4B

Cancer Funding

Specific Cancer Types(3)

Name	Centers	Active Trials
Deleterious BRCA2 Gene Mutation	48	7
Germline BRCA1 Gene Mutation	4	4
Germline BRCA2 Gene Mutation	4	4

Top Centers for BRCA2 Gene Mutation(68)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	4	—	72.0
2	Rutgers Cancer InstituteNew Brunswick, NJ NCI Comprehensive High-Volume Research Center	High-Volume Research Center	1	—	72.0
3	Boston University Cancer CenterBoston, MA High-Volume Research Center	High-Volume Research Center	4	—	72.0
4	Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	—	$1M	67.0
5	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive		2	—	49.5
6	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive		—	—	49.5
7	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive		—	—	49.5
8	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive		1	—	49.5
9	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive		1	—	49.5
10	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive		—	—	49.5
11	Vanderbilt-Ingram Cancer CenterNashville, TN NCI Comprehensive		2	—	49.5
12	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive		—	—	49.5
13	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive		—	—	49.5
14	Dan L Duncan Comprehensive Cancer Center at Baylor College of MedicineHouston, TX NCI Comprehensive		—	—	49.5
15	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive		—	—	49.5
16	Duke Cancer InstituteDurham, NC NCI Comprehensive		—	—	49.5
17	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive		—	—	49.5
18	Simmons Comprehensive Cancer Center UT Southwestern Medical CenterDallas, TX NCI Comprehensive		—	—	49.5
19	Winship Cancer InstituteAtlanta, GA NCI Comprehensive		—	—	49.5
20	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive		—	—	49.5
21	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive		—	—	49.5
22	USC Norris Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive		—	—	49.5
23	University of Colorado Cancer CenterAurora, CO NCI Comprehensive		—	—	49.5
24	Moffitt Cancer CenterTampa, FL NCI Comprehensive		—	—	49.5
25	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive		—	—	49.5
26	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive		—	—	49.5
27	Montefiore Einstein Comprehensive Cancer CenterBronx, NY NCI Comprehensive		—	—	49.5
28	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive		—	—	49.5
29	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive		—	—	49.5
30	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive		—	—	49.5
31	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive		—	—	49.5
32	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical		—	—	49.5
33	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive		—	—	49.5
34	Medical College of Wisconsin Cancer CenterMilwaukee, WI		—	—	49.5
35	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive		—	—	49.5
36	Cleveland Clinic Cancer CenterCleveland, OH		—	—	49.5
37	Holden Comprehensive Cancer CenterIowa City, IA NCI Comprehensive		—	—	49.5
38	Georgetown Lombardi Comprehensive Cancer CenterWashington, DC NCI Comprehensive		—	—	49.5
39	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical		—	—	49.5
40	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive		—	—	49.5
41	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive		—	—	49.5
42	Dartmouth Cancer CenterLebanon, NH NCI Comprehensive		—	—	49.5
43	University of Illinois Cancer CenterChicago, IL		1	—	49.5
44	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical		—	—	49.5
45	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive		—	—	49.5
46	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR		—	—	49.5
47	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive		—	—	49.5
48	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive		—	—	49.5
49	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX		—	—	49.5
50	Cancer Center at IllinoisUrbana, IL		1	—	49.5
51	Stony Brook Cancer CenterStony Brook, NY		—	—	49.5
52	Penn State Cancer InstituteHershey, PA		—	—	49.5
53	The Jackson Laboratory Cancer CenterBar Harbor, ME NCI Basic_laboratory		—	—	49.5
54	University of Cincinnati Cancer CenterCincinnati, OH		—	—	49.5
55	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL		—	—	49.5
56	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ		—	—	49.5
57	Georgia Cancer Center, Augusta UniversityAugusta, GA		—	—	49.5
58	The University of Vermont Cancer CenterBurlington, VT		—	—	49.5
59	Upstate Cancer CenterSyracuse, NY		—	—	49.5
60	University of Texas Medical Branch Cancer CenterGalveston, TX		—	—	49.5
61	Loma Linda University Cancer CenterLoma Linda, CA		—	—	49.5
62	Tampa General Hospital Cancer InstituteTampa, FL		—	—	49.5
63	Murtha Cancer Center at Walter Reed BethesdaBethesda, MD		—	—	49.5
64	Louisiana Cancer Research CenterNew Orleans, LA		—	—	49.5
65	Princess Margaret Cancer CentreToronto, ON		—	—	49.5
66	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive		1	$911M	—
67	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive		—	$368M	—
68	UMass Memorial Health Cancer CenterWorcester, MA		—	$155M	—

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →