Lynch Syndrome

specific

An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present.

Centers

Active Trials

$37M

Cancer Funding

Top Centers for Lynch Syndrome(75)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	4	$2M	86.8
2	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive High-Volume Research Center	High-Volume Research Center	2	$5M	82.6
3	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive High-Volume Research Center	High-Volume Research Center	4	$196K	81.6
4	University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program	Active Research Program	5	—	69.1
5	University of Illinois Cancer CenterChicago, IL Active Research Program	Active Research Program	4	—	67.6
6	Boston University Cancer CenterBoston, MA Active Research Program	Active Research Program	4	—	67.6
7	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	3	—	65.8
8	University of Puerto Rico Comprehensive Cancer CenterSan Juan, PR Active Research Program	Active Research Program	3	—	65.8
9	OHSU Knight Cancer InstitutePortland, OR NCI Comprehensive Active Research Program	Active Research Program	1	$6M	65.1
10	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	1	$2M	62.7
11	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	2	—	62.5
12	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive Active Research Program	Active Research Program	2	—	62.5
13	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive Active Research Program	Active Research Program	2	—	62.5
14	Cleveland Clinic Cancer CenterCleveland, OH Active Research Program	Active Research Program	2	—	62.5
15	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical Active Research Program	Active Research Program	2	—	62.5
16	University of Cincinnati Cancer CenterCincinnati, OH Active Research Program	Active Research Program	2	—	62.5
17	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL Active Research Program	Active Research Program	2	—	62.5
18	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ Active Research Program	Active Research Program	2	—	62.5
19	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive Active Research Program	Active Research Program	1	$1M	61.8
20	UNC Lineberger Comprehensive Cancer CenterChapel Hill, NC NCI Comprehensive Active Research Program	Active Research Program	1	$996K	61.3
21	The University of Vermont Cancer CenterBurlington, VT Active Research Program	Active Research Program	1	$746K	59.9
22	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive Active Research Program	Active Research Program	1	$320K	59.5
23	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	1	$306K	59.0
24	Sandra and Edward Meyer Cancer Center at Weill Cornell MedicineNew York, NY Active Research Program	Active Research Program	—	$9M	47.8
25	Montefiore Einstein Comprehensive Cancer CenterBronx, NY NCI Comprehensive Active Research Program	Active Research Program	—	$4M	46.4
26	Robert H. Lurie Comprehensive Cancer Center of Northwestern UniversityChicago, IL NCI Comprehensive Active Research Program	Active Research Program	—	$2M	45.5
27	Mount Sinai Tisch Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$2M	44.6
28	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
29	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
30	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
31	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
32	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
33	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
34	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
35	Duke Cancer InstituteDurham, NC NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
36	Simmons Comprehensive Cancer Center UT Southwestern Medical CenterDallas, TX NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
37	Laura and Isaac Perlmutter Cancer Center at NYU Langone HealthNew York, NY NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
38	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
39	USC Norris Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
40	Comprehensive Cancer Center St. Jude Children’s Research HospitalMemphis, TN NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
41	Moffitt Cancer CenterTampa, FL NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
42	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
43	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
44	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
45	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
46	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
47	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical Active Research Program	Active Research Program	1	—	44.5
48	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
49	Medical College of Wisconsin Cancer CenterMilwaukee, WI Active Research Program	Active Research Program	1	—	44.5
50	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
51	Holden Comprehensive Cancer CenterIowa City, IA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
52	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
53	Dartmouth Cancer CenterLebanon, NH NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
54	Rutgers Cancer InstituteNew Brunswick, NJ NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
55	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical Active Research Program	Active Research Program	1	—	44.5
56	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
57	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR Active Research Program	Active Research Program	1	—	44.5
58	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive Active Research Program	Active Research Program	1	—	44.5
59	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX Active Research Program	Active Research Program	1	—	44.5
60	Cancer Center at IllinoisUrbana, IL Active Research Program	Active Research Program	1	—	44.5
61	Stony Brook Cancer CenterStony Brook, NY Active Research Program	Active Research Program	1	—	44.5
62	Penn State Cancer InstituteHershey, PA Active Research Program	Active Research Program	1	—	44.5
63	The Jackson Laboratory Cancer CenterBar Harbor, ME NCI Basic_laboratory Active Research Program	Active Research Program	1	—	44.5
64	Livestrong Cancer InstitutesAustin, TX Active Research Program	Active Research Program	1	—	44.5
65	Georgia Cancer Center, Augusta UniversityAugusta, GA Active Research Program	Active Research Program	1	—	44.5
66	Ellis Fischel Cancer Center, MU Health CareColumbia, MO Active Research Program	Active Research Program	1	—	44.5
67	Upstate Cancer CenterSyracuse, NY Active Research Program	Active Research Program	1	—	44.5
68	University of Texas Medical Branch Cancer CenterGalveston, TX Active Research Program	Active Research Program	1	—	44.5
69	Louisiana Cancer Research CenterNew Orleans, LA Active Research Program	Active Research Program	1	—	44.5
70	Murtha Cancer Center at Walter Reed BethesdaBethesda, MD Active Research Program	Active Research Program	1	—	44.5
71	Princess Margaret Cancer CentreToronto, ON Active Research Program	Active Research Program	1	—	44.5
72	O’Neal Comprehensive Cancer Center at the University of Alabama at BirminghamBirmingham, AL NCI Comprehensive Active Research Program	Active Research Program	—	$815K	43.2
73	Atrium Health Wake Forest Baptist Comprehensive Cancer CenterWinston-Salem, NC NCI Comprehensive Active Research Program	Active Research Program	—	$758K	42.7
74	University of Wisconsin Carbone Cancer CenterMadison, WI NCI Comprehensive		—	—	26.8
75	BC CancerVancouver, BC		—	—	26.8

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →