Gemcitabine

specific

A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucl

Centers

Active Trials

$81M

Cancer Funding

Top Centers for Gemcitabine(48)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$6M	68.2
2	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical Active Research Program	Active Research Program	—	$6M	67.4
3	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	—	$6M	66.7
4	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$6M	66.0
5	UNC Lineberger Comprehensive Cancer CenterChapel Hill, NC NCI Comprehensive Active Research Program	Active Research Program	—	$6M	65.3
6	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive Active Research Program	Active Research Program	—	$5M	64.5
7	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive Active Research Program	Active Research Program	—	$4M	63.8
8	UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, CA NCI Comprehensive Active Research Program	Active Research Program	—	$4M	63.1
9	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive Active Research Program	Active Research Program	—	$4M	62.3
10	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive Active Research Program	Active Research Program	—	$4M	61.6
11	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	—	$4M	60.9
12	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	—	$3M	60.2
13	O’Neal Comprehensive Cancer Center at the University of Alabama at BirminghamBirmingham, AL NCI Comprehensive Active Research Program	Active Research Program	—	$3M	59.4
14	Wilmot Cancer Institute, UR MedicineRochester, NY NCI Clinical Active Research Program	Active Research Program	—	$2M	58.7
15	University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program	Active Research Program	—	$2M	58.0
16	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	—	$2M	57.2
17	University of Cincinnati Cancer CenterCincinnati, OH Active Research Program	Active Research Program	—	$2M	56.5
18	Georgia Cancer Center, Augusta UniversityAugusta, GA Active Research Program	Active Research Program	—	$2M	55.8
19	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive Active Research Program	Active Research Program	—	$1M	55.1
20	UCI Chao Family Comprehensive Cancer CenterOrange, CA NCI Comprehensive Active Research Program	Active Research Program	—	$1M	54.3
21	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	—	$1M	53.6
22	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive Active Research Program	Active Research Program	—	$1M	52.9
23	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive Active Research Program	Active Research Program	—	$996K	52.1
24	UofL James Graham Brown Cancer CenterLouisville, KY Active Research Program	Active Research Program	—	$950K	51.4
25	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX Active Research Program	Active Research Program	—	$945K	50.7
26	Hollings Cancer CenterCharleston, SC NCI Clinical Active Research Program	Active Research Program	—	$817K	49.9
27	Stephenson Cancer CenterOklahoma City, OK NCI Clinical Active Research Program	Active Research Program	—	$678K	49.2
28	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive Active Research Program	Active Research Program	—	$344K	48.5
29	Salk Institute Cancer CenterLa Jolla, CA NCI Basic_laboratory Active Research Program	Active Research Program	—	$272K	47.8
30	Stony Brook Cancer CenterStony Brook, NY Active Research Program	Active Research Program	—	$249K	47.0
31	Cleveland Clinic Cancer CenterCleveland, OH Active Research Program	Active Research Program	—	$98K	46.3
32	Boston University Cancer CenterBoston, MA Active Research Program	Active Research Program	—	$51K	45.6
33	Vanderbilt-Ingram Cancer CenterNashville, TN NCI Comprehensive		—	—	39.4
34	Moffitt Cancer CenterTampa, FL NCI Comprehensive		—	—	39.4
35	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive		—	—	39.4
36	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical		—	—	39.4
37	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive		—	—	39.4
38	Medical College of Wisconsin Cancer CenterMilwaukee, WI		—	—	39.4
39	University of Illinois Cancer CenterChicago, IL		—	—	39.4
40	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive		—	—	39.4
41	Cancer Center at IllinoisUrbana, IL		—	—	39.4
42	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL		—	—	39.4
43	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ		—	—	39.4
44	Upstate Cancer CenterSyracuse, NY		—	—	39.4
45	University of Texas Medical Branch Cancer CenterGalveston, TX		—	—	39.4
46	Princess Margaret Cancer CentreToronto, ON		—	—	39.4
47	Louisiana Cancer Research CenterNew Orleans, LA		—	—	39.4
48	Tampa General Hospital Cancer InstituteTampa, FL		—	—	39.4

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →