Esophageal Adenocarcinoma

general

A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor.

Centers

186

Active Trials

$2.2B

Cancer Funding

Specific Cancer Types(3)

Name	Centers	Active Trials
Unresectable Esophageal Adenocarcinoma	59	87
Recurrent Esophageal Adenocarcinoma	15	15
Distal Esophageal Adenocarcinoma	3	—

Top Centers for Esophageal Adenocarcinoma(80)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	University of Colorado Cancer CenterAurora, CO NCI Comprehensive High-Volume Research Center	High-Volume Research Center	11	$9M	89.1
2	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive High-Volume Research Center	High-Volume Research Center	6	$2M	83.9
3	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive High-Volume Research Center	High-Volume Research Center	3	$5M	82.3
4	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	2	$6M	78.2
5	Boston University Cancer CenterBoston, MA High-Volume Research Center	High-Volume Research Center	6	$375K	76.1
6	Vanderbilt-Ingram Cancer CenterNashville, TN NCI Comprehensive High-Volume Research Center	High-Volume Research Center	3	$2M	74.0
7	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	4	$209K	72.0
8	Case Comprehensive Cancer CenterCleveland, OH NCI Comprehensive High-Volume Research Center	High-Volume Research Center	1	$22M	70.4
9	Mayo Clinic Comprehensive Cancer Center, ArizonaScottsdale, AZ Active Research Program	Active Research Program	2	$678K	68.9
10	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	1	$4M	67.4
11	Cleveland Clinic Cancer CenterCleveland, OH Active Research Program	Active Research Program	7	—	64.6
12	University of Illinois Cancer CenterChicago, IL Active Research Program	Active Research Program	9	—	64.6
13	Duke Cancer InstituteDurham, NC NCI Comprehensive Active Research Program	Active Research Program	1	$1M	63.7
14	Mayo Clinic Comprehensive Cancer Center, FloridaJacksonville, FL Active Research Program	Active Research Program	5	—	62.9
15	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	2	$789K	61.2
16	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	4	—	60.9
17	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	4	—	60.9
18	University of Virginia Cancer CenterCharlottesville, VA NCI Comprehensive Active Research Program	Active Research Program	6	—	60.9
19	UNC Lineberger Comprehensive Cancer CenterChapel Hill, NC NCI Comprehensive Active Research Program	Active Research Program	3	—	56.3
20	UCLA Jonsson Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive Active Research Program	Active Research Program	2	—	56.3
21	Moffitt Cancer CenterTampa, FL NCI Comprehensive Active Research Program	Active Research Program	2	—	56.3
22	The University of Arizona Cancer CenterTucson, AZ NCI Comprehensive Active Research Program	Active Research Program	4	—	56.3
23	Cancer Center at IllinoisUrbana, IL Active Research Program	Active Research Program	5	—	56.3
24	Princess Margaret Cancer CentreToronto, ON Active Research Program	Active Research Program	2	—	56.3
25	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	1	$24M	55.1
26	Sylvester Comprehensive Cancer CenterMiami, FL NCI Clinical Active Research Program	Active Research Program	2	$8M	53.5
27	UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, CA NCI Comprehensive Active Research Program	Active Research Program	—	$4M	52.0
28	USC Norris Comprehensive Cancer CenterLos Angeles, CA NCI Comprehensive Active Research Program	Active Research Program	2	$3M	51.0
29	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive Active Research Program	Active Research Program	1	$2M	49.9
30	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive Active Research Program	Active Research Program	1	$2M	49.4
31	Wilmot Cancer Institute, UR MedicineRochester, NY NCI Clinical Active Research Program	Active Research Program	1	$2M	48.4
32	Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	—	$1M	47.4
33	Siteman Cancer CenterSt. Louis, MO NCI Comprehensive Active Research Program	Active Research Program	2	—	47.0
34	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive Active Research Program	Active Research Program	2	—	47.0
35	The University of Chicago Medicine Comprehensive Cancer CenterChicago, IL NCI Comprehensive Active Research Program	Active Research Program	3	—	47.0
36	University of Wisconsin Carbone Cancer CenterMadison, WI NCI Comprehensive Active Research Program	Active Research Program	4	—	47.0
37	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive Active Research Program	Active Research Program	4	—	47.0
38	Dartmouth Cancer CenterLebanon, NH NCI Comprehensive Active Research Program	Active Research Program	1	—	47.0
39	Stephenson Cancer CenterOklahoma City, OK NCI Clinical Active Research Program	Active Research Program	1	—	47.0
40	Rutgers Cancer InstituteNew Brunswick, NJ NCI Comprehensive Active Research Program	Active Research Program	2	—	47.0
41	University of New Mexico Comprehensive Cancer CenterAlbuquerque, NM NCI Comprehensive Active Research Program	Active Research Program	3	—	47.0
42	Karmanos Cancer InstituteDetroit, MI NCI Comprehensive Active Research Program	Active Research Program	2	—	47.0
43	Houston Methodist Dr. Mary and Ron Neal Cancer CenterHouston, TX Active Research Program	Active Research Program	2	—	47.0
44	Penn State Cancer InstituteHershey, PA Active Research Program	Active Research Program	2	—	47.0
45	Legorreta Cancer Center at Brown UniversityProvidence, RI Active Research Program	Active Research Program	1	—	47.0
46	Tampa General Hospital Cancer InstituteTampa, FL Active Research Program	Active Research Program	1	—	47.0
47	Louisiana Cancer Research CenterNew Orleans, LA Active Research Program	Active Research Program	4	—	47.0
48	Simmons Comprehensive Cancer Center UT Southwestern Medical CenterDallas, TX NCI Comprehensive Active Research Program	Active Research Program	1	$1M	46.8
49	Atrium Health Wake Forest Baptist Comprehensive Cancer CenterWinston-Salem, NC NCI Comprehensive Active Research Program	Active Research Program	1	$949K	46.3
50	Dan L Duncan Comprehensive Cancer Center at Baylor College of MedicineHouston, TX NCI Comprehensive Active Research Program	Active Research Program	1	$795K	45.8
51	Cedars-Sinai CancerLos Angeles, CA Active Research Program	Active Research Program	1	$776K	44.8
52	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive Active Research Program	Active Research Program	1	$719K	44.3
53	Medical College of Wisconsin Cancer CenterMilwaukee, WI Active Research Program	Active Research Program	2	$426K	43.2
54	Winship Cancer InstituteAtlanta, GA NCI Comprehensive		2	—	31.1
55	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive		3	—	31.1
56	OHSU Knight Cancer InstitutePortland, OR NCI Comprehensive		—	—	31.1
57	City of Hope Comprehensive Cancer CenterDuarte, CA NCI Comprehensive		2	—	31.1
58	Huntsman Cancer Institute at the University of UtahSalt Lake City, UT NCI Comprehensive		2	—	31.1
59	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive		2	—	31.1
60	Holden Comprehensive Cancer CenterIowa City, IA NCI Comprehensive		1	—	31.1
61	Georgetown Lombardi Comprehensive Cancer CenterWashington, DC NCI Comprehensive		2	—	31.1
62	Fred & Pamela Buffett Cancer CenterOmaha, NE NCI Clinical		3	—	31.1
63	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR		2	—	31.1
64	Fox Chase Cancer CenterPhiladelphia, PA NCI Comprehensive		1	—	31.1
65	The Jackson Laboratory Cancer CenterBar Harbor, ME NCI Basic_laboratory		—	—	31.1
66	University of Cincinnati Cancer CenterCincinnati, OH		2	—	31.1
67	The University of Vermont Cancer CenterBurlington, VT		2	—	31.1
68	University of Texas Medical Branch Cancer CenterGalveston, TX		1	—	31.1
69	Laura and Isaac Perlmutter Cancer Center at NYU Langone HealthNew York, NY NCI Comprehensive		1	$392M	—
70	Masonic Cancer CenterMinneapolis, MN NCI Comprehensive		2	$368M	—
71	UF Health Cancer InstituteGainesville, FL NCI Clinical		1	$257M	—
72	Montefiore Einstein Comprehensive Cancer CenterBronx, NY NCI Comprehensive		1	$246M	—
73	UCI Chao Family Comprehensive Cancer CenterOrange, CA NCI Comprehensive		1	$185M	—
74	VCU Massey Comprehensive Cancer CenterRichmond, VA NCI Comprehensive		2	$163M	—
75	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive		2	$136M	—
76	University of Hawai‘i Cancer CenterHonolulu, HI NCI Clinical		2	$116M	—
77	Stony Brook Cancer CenterStony Brook, NY		1	$79M	—
78	UofL James Graham Brown Cancer CenterLouisville, KY		1	$59M	—
79	University of Puerto Rico Comprehensive Cancer CenterSan Juan, PR		1	$34M	—
80	Northwell Health Cancer InstituteNew York, NY		2	$18M	—

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →