Chromosomal Instability

specific

The instability of chromosomes is attributed to the continuous formation of novel chromosome mutations. These mutations form at an elevated rate in comparison to the normal cell population. The increased frequency of structural chromosome aberrations can be caused by an abnormally high incidence of DNA double-strand breaks and translocations. Screening for chromosomal breakage and rearrangement is used as a diagnostic tool in Fanconi anemia.

Centers

Active Trials

$71M

Cancer Funding

Top Centers for Chromosomal Instability(36)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Research Tier	Active Trials	Cancer Funding	Score
1	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive High-Volume Research Center	High-Volume Research Center	1	$19M	82.2
2	UAMS Winthrop P. Rockefeller Cancer InstituteLittle Rock, AR High-Volume Research Center	High-Volume Research Center	1	$2M	73.4
3	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive High-Volume Research Center	High-Volume Research Center	1	$2M	72.4
4	University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program	Active Research Program	1	$2M	69.5
5	Roswell Park Comprehensive Cancer CenterBuffalo, NY NCI Comprehensive Active Research Program	Active Research Program	1	$786K	63.7
6	University of Michigan Rogel Cancer CenterAnn Arbor, MI NCI Comprehensive Active Research Program	Active Research Program	—	$9M	58.7
7	Sandra and Edward Meyer Cancer Center at Weill Cornell MedicineNew York, NY Active Research Program	Active Research Program	—	$6M	57.7
8	University of Wisconsin Carbone Cancer CenterMadison, WI NCI Comprehensive Active Research Program	Active Research Program	—	$4M	56.7
9	UofL James Graham Brown Cancer CenterLouisville, KY Active Research Program	Active Research Program	—	$3M	55.8
10	UC Davis Comprehensive Cancer CenterSacramento, CA NCI Comprehensive Active Research Program	Active Research Program	—	$3M	54.8
11	Stanford Cancer InstitutePalo Alto, CA NCI Comprehensive Active Research Program	Active Research Program	—	$3M	53.8
12	UC San Diego Moores Cancer CenterLa Jolla, CA NCI Comprehensive Active Research Program	Active Research Program	—	$2M	52.8
13	Fred Hutch Cancer CenterSeattle, WA NCI Comprehensive Active Research Program	Active Research Program	1	—	52.0
14	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive Active Research Program	Active Research Program	1	—	52.0
15	Hollings Cancer CenterCharleston, SC NCI Clinical Active Research Program	Active Research Program	1	—	52.0
16	Medical College of Wisconsin Cancer CenterMilwaukee, WI Active Research Program	Active Research Program	1	—	52.0
17	Stephenson Cancer CenterOklahoma City, OK NCI Clinical Active Research Program	Active Research Program	1	—	52.0
18	University of Illinois Cancer CenterChicago, IL Active Research Program	Active Research Program	1	—	52.0
19	Boston University Cancer CenterBoston, MA Active Research Program	Active Research Program	1	—	52.0
20	University of Cincinnati Cancer CenterCincinnati, OH Active Research Program	Active Research Program	1	—	52.0
21	Georgia Cancer Center, Augusta UniversityAugusta, GA Active Research Program	Active Research Program	1	—	52.0
22	Herbert Irving Comprehensive Cancer CenterNew York, NY NCI Comprehensive Active Research Program	Active Research Program	—	$2M	51.9
23	Mayo Clinic Comprehensive Cancer CenterRochester, MN NCI Comprehensive Active Research Program	Active Research Program	—	$2M	49.0
24	Cedars-Sinai CancerLos Angeles, CA Active Research Program	Active Research Program	—	$2M	48.0
25	University of Texas Medical Branch Cancer CenterGalveston, TX Active Research Program	Active Research Program	—	$2M	46.0
26	Stony Brook Cancer CenterStony Brook, NY Active Research Program	Active Research Program	—	$2M	45.1
27	UPMC Hillman Cancer CenterPittsburgh, PA NCI Comprehensive Active Research Program	Active Research Program	—	$1M	44.1
28	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins UniversityBaltimore, MD NCI Comprehensive Active Research Program	Active Research Program	—	$1M	43.1
29	The University of Kansas Cancer CenterKansas City, KS NCI Comprehensive Active Research Program	Active Research Program	—	$982K	42.2
30	Yale Cancer Center Yale School of MedicineNew Haven, CT NCI Comprehensive Active Research Program	Active Research Program	—	$702K	40.2
31	The Ohio State University Comprehensive Cancer Center - James Cancer Hospital & Solove Research InstituteColumbus, OH NCI Comprehensive Active Research Program	Active Research Program	—	$562K	39.2
32	Cleveland Clinic Cancer CenterCleveland, OH Active Research Program	Active Research Program	—	$512K	38.3
33	UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, CA NCI Comprehensive Active Research Program	Active Research Program	—	$246K	37.3
34	Sidney Kimmel Comprehensive Cancer Center at JeffersonPhiladelphia, PA NCI Comprehensive Active Research Program	Active Research Program	—	$99K	36.3
35	Duke Cancer InstituteDurham, NC NCI Comprehensive Active Research Program	Active Research Program	—	$97K	35.3
36	Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, IN NCI Comprehensive Contributing Research Center	Contributing Research Center	—	$97K	34.4

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →