Melanoma (Part E)

specific

Five distinct stages have been proposed in the evolution of melanoma on the basis of histological criteria: common acquired and congenital nevi without dysplastic changes; dysplastic nevi with structural and architectural atypia; radial-growth phase (RGP) melanoma; vertical-growth phase (VGP) melanoma; and metastatic melanoma. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-A

Centers

Active Trials

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Cancer Funding

Top Centers for Melanoma (Part E)(4)

Ranked by research excellence score (trials · grants · publications). Methodology →

#	Center	Active Trials	Cancer Funding	Score
1	Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive	—	—	62.5
2	Dana-Farber Cancer InstituteBoston, MA NCI Comprehensive	—	—	62.5
3	The University of Texas MD Anderson Cancer CenterHouston, TX NCI Comprehensive	—	—	62.5
4	Boston University Cancer CenterBoston, MA	—	—	62.5

Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →