Constitutional Mismatch Repair Deficiency Syndrome
specificA rare childhood cancer predisposition syndrome caused by biallelic inheritance of mutations in MLH1, MSH2, MSH6, or PMS2 genes. It is characterized by the development of childhood cancers, usually hematological malignancies and/or brain tumors, and colorectal cancers with multiple intestinal polyps. The majority of patients show signs of neurofibromatosis type 1.
7
Centers
5
Active Trials
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Cancer Funding
Top Centers for Constitutional Mismatch Repair Deficiency Syndrome(7)
Ranked by research excellence score (trials · grants · publications). Methodology →
| # | Center | Score |
|---|---|---|
| 1 | Memorial Sloan Kettering Cancer CenterNew York, NY NCI Comprehensive Active Research Program | 63.6 |
| 2 | NCI Comprehensive Active Research Program | 63.6 |
| 3 | University of Colorado Cancer CenterAurora, CO NCI Comprehensive Active Research Program | 63.6 |
| 4 | University of Illinois Cancer CenterChicago, IL Active Research Program | 63.6 |
| 5 | University of Cincinnati Cancer CenterCincinnati, OH Active Research Program | 63.6 |
| 6 | NCI Comprehensive | 41.1 |
| 7 | BC CancerVancouver, BC | 41.1 |
Research tier badges reflect trial volume, NIH grant funding, and publication impact — not clinical outcomes or patient satisfaction. Learn about our methodology →