Multicentric Castleman Disease

Castleman disease characterized by fever, generalized lymphadenopathy, hypergammaglobulinemia, and dysfunction of multiple organs. Other signs and symptoms include anemia, thrombocytopenia, hepatomegaly, peripheral neuropathy and pleural effusions. Morphologically, in the majority of cases the lymph nodes show features of Castleman disease of the plasma cell type. In a minority of cases, changes of Castleman disease of the hyaline-vascular type are seen. In contrast to patients with localized